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Your search on creator:Tremellen found these results. 1 to 10 of 23 records in 17.47s



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Oxidative stress and male infertility - a clinical perspective

Author/Creator: Tremellen, Kelton Paul
Resource type: journal article
Date: 2008, 2009
Subject: oxidative stress; sperm; male infertility; antioxidant; treatment options
Record contributed by: The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/51907
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.volume=14&rft.atitle=(MS)+Oxidative+stress+and+male+infertility+-+a+clinical+perspective&rft.aulast=Tremellen&rft.place=Great+Clarendon+St+Oxford+England+OX2+6DP&rft.spage=243&rft.issn=13554786&rft.jtitle=Human+Reproduction+Update&rft.issue=3&rft.epage=258&rft.pub=Oxford+Univ+Press&rft.pages=243-258
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http://hdl.handle.net/2440/51907
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.volume=14&rft.atitle=(MS)+Oxidative+stress+and+male+infertility+-+a+clinical+perspective&rft.aulast=Tremellen&rft.place=Great+Clarendon+St+Oxford+England+OX2+6DP&rft.spage=243&rft.issn=13554786&rft.jtitle=Human+Reproduction+Update&rft.issue=3&rft.epage=258&rft.pub=Oxford+Univ+Press&rft.pages=243-258

Description
Copyright © The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

Oxidative stress occurs when the production of potentially destructive reactive oxygen species (ROS) exceeds the bodies own natural antioxidant defenses, resulting in cellular damage. Oxidative stress is a common pathology seen in approximately half of all infertile men. ROS, defined as including oxygen ions, free radicals and peroxides are generated by sperm and seminal leukocytes within semen and produce infertility by two key mechanisms. First, they damage the sperm membrane, decreasing sperm motility and its ability to fuse with the oocyte. Second, ROS can alter the sperm DNA, resulting in the passage of defective paternal DNA on to the conceptus. This review will provide an overview of oxidative biochemistry related to sperm health and will identify which men are most at risk of oxidative infertility. Finally, the review will outline methods available for diagnosing oxidative stress and the various treatments available.

Kelton Tremellen

Publisher: Oxford University Press
Contributor: School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology

Other identifier: Human Reproduction Update, 2008; 14 (3):243-258; 1355-4786; 0020080544; 10.1093/humupd/dmn004; 000255151400005
Language: en
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Oxidative stress occurs when the production of potentially destructive reactive oxygen species (ROS) exceeds the bodies own natural antioxidant defenses, resulting in cellular damage. Oxidative stress is a common pathology seen in approximately half of all ...
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The immunoregulatory role of seminal plasma in early murine and human pregnancy / Kelton Paul Tremellen.

Author/Creator: Tremellen, Kelton Paul
Resource type: thesis
Date: 1998
Subject: Reproduction Physiological aspects., Spermatozoa Physiology., Granulocyte-macrophage colony-stimulating factor
Record contributed by: Australasian Digital Theses Program, The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/19406
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http://hdl.handle.net/2440/19406

Description
Errata posted inside back end-paper (leaf 250).

Bibliography: leaves 204-249.

xxiv, 250 leaves, [8] leaves of plates : ill. (some col.) ; 30 cm.

Title page, contents and abstract only. The complete thesis in print form is available from the University Library.

Investigates the nature of the seminal vesicle-derived trigger(s) that stimulate the granulocyte-macrophage colony-stimulating factor release from the murine uterine epithelium.

Thesis (Ph.D.)--University of Adelaide, Dept. of Obstetrics and Gynaecology, 1999


Language: en_US
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Investigates the nature of the seminal vesicle-derived trigger(s) that stimulate the granulocyte-macrophage colony-stimulating factor release from the murine uterine epithelium.
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Seminal 'Priming' for Successful Mammalian Pregnancy

Author/Creator: Tremellen, K. P., Robertson, Sarah A.
Resource type: book chapter
Date: 1999, 2007
Subject: No Subjects
Record contributed by: The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/30846
http://link.library.adelaide.edu.au/?atitle=Seminal%20'Priming'%20for%20Successful%20Mammalian%20Pregnancy&aulast=Tremellen&title=Reproductive%20Immunology&date=1999&pages=88-98&spage=88&epage=98
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http://hdl.handle.net/2440/30846
http://link.library.adelaide.edu.au/?atitle=Seminal%20'Priming'%20for%20Successful%20Mammalian%20Pregnancy&aulast=Tremellen&title=Reproductive%20Immunology&date=1999&pages=88-98&spage=88&epage=98

Description
None Available

Publisher: Narosa Publishing House
Contributor: School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology

Other identifier: Reproductive Immunology. pp.88-98
Language: en
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None Available
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Oxidative DNA damage impairs global sperm DNA methylation in infertile men

Author/Creator: Tunc, Ozlem, Tremellen, Kelton Paul
Resource type: journal article
Date: 2009, 2010
Subject: No Subjects
Record contributed by: The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/55098
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.place=233+Spring+St+New+York+NY+10013&rft.issn=10580468&rft.pub=Kluwer+Academic/Plenum+Publ&rft.volume=2009&rft.atitle=Oxidative+DNA+damage+impairs+global+sperm+DNA+methylation+in+infertile+men&rft.aulast=Tunc&rft.spage=1&rft.jtitle=Journal+of+Assisted+Reproduction+and+Genetics&rft.epage=8&rft.pages=1-8
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http://hdl.handle.net/2440/55098
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.place=233+Spring+St+New+York+NY+10013&rft.issn=10580468&rft.pub=Kluwer+Academic/Plenum+Publ&rft.volume=2009&rft.atitle=Oxidative+DNA+damage+impairs+global+sperm+DNA+methylation+in+infertile+men&rft.aulast=Tunc&rft.spage=1&rft.jtitle=Journal+of+Assisted+Reproduction+and+Genetics&rft.epage=8&rft.pages=1-8

Description
Purpose: Methylation of sperm DNA is impaired in many infertile men potentially adversely effecting reproductive outcomes. In somatic cells oxidative damage to DNA and hyperhomocysteinaemia are linked with DNA hypomethylation. The objective of this study was to investigate if these pathologies also impair sperm DNA methylation. Methods: The relationship between sperm DNA quality, oxidative stress and serum homocysteine was analysed at study entry and after 3 months of antioxidant treatment. Results: Overall a significant negative correlation was observed between sperm DNA methylation and sperm DNA fragmentation, as well as seminal reactive oxygen species (ROS) production. Sperm DNA methylation was not significantly related to serum homocysteine concentrations. Administration of an antioxidant supplement produced a significant fall in seminal ROS levels and sperm DNA fragmentation, while increasing sperm DNA methylation. Conclusions: These results suggest that oxidative stress related damage to sperm DNA impedes the process ofmethylation, while antioxidant supplementation appears to have the potential to reduce DNA damage and normalize sperm DNA methylation.

Ozlem Tunc and Kelton Tremellen

Publisher: Springer
Contributor: School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology

Other identifier: Journal of Assisted Reproduction and Genetics, 2009; 26(9-10):837-544; 1058-0468; 0020093230; 10.1007/s10815-009-9346-2; 000272428800009
Language: en
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Purpose: Methylation of sperm DNA is impaired in many infertile men potentially adversely effecting reproductive outcomes. In somatic cells oxidative damage to DNA and hyperhomocysteinaemia are linked with DNA hypomethylation. The objective of this study was ...
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Macrophage activity in semen is significantly correlated with sperm quality in infertile men

Author/Creator: Tremellen, Kelton Paul, Tunc, Ozlem
Resource type: journal article
Date: 2010
Subject: DNA; elastase; leucocyte; macrophage; neopterin; sperm
Record contributed by: The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/59837
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.volume=33&rft.atitle=Macrophage+activity+in+semen+is+significantly+correlated+with+sperm+quality+in+infertile+men&rft.aulast=Tremellen&rft.place=P+O+Box+88+Osney+Mead+Oxford+England+OX2+0NE&rft.spage=1&rft.issn=01056263&rft.jtitle=International+Journal+of+Andrology&rft.epage=9&rft.pub=Blackwell+Science+Ltd&rft.pages=1-9
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http://hdl.handle.net/2440/59837
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.volume=33&rft.atitle=Macrophage+activity+in+semen+is+significantly+correlated+with+sperm+quality+in+infertile+men&rft.aulast=Tremellen&rft.place=P+O+Box+88+Osney+Mead+Oxford+England+OX2+0NE&rft.spage=1&rft.issn=01056263&rft.jtitle=International+Journal+of+Andrology&rft.epage=9&rft.pub=Blackwell+Science+Ltd&rft.pages=1-9

Description
The presence of leucocytes within semen has the potential to impair sperm function. Neutrophils and macrophages make up 95% of seminal leucocytes, with both having the ability to damage sperm via the generation of reactive oxygen species, proteases and the induction of apoptosis. Existing cytological techniques for quantifying leucocyte activity within semen (peroxidase, CD45) are less than ideal as they merely count the number of leucocytes, rather than assess their activity. Seminal plasma elastase effectively determines neutrophil activity, yet gives no insight into macrophage activity. Neopterin, a molecule released from activated macrophages, may be a useful marker for macrophage activity in the male reproductive tract. To examine this possibility a total of 63 asymptomatic subjects with male factor infertility and 11 fertile controls provided semen samples for measurement of various inflammatory markers. We were able to confirm for the first time that seminal plasma does indeed contain neopterin and that the levels of this macrophage activity marker are threefold higher in infertile than fertile men. Furthermore, seminal plasma neopterin concentration was significantly correlated with sperm oxidative stress, DNA fragmentation (TUNEL) and apoptosis (Annexin V), making it a useful marker of sperm quality. By contrast, seminal plasma elastase showed no correlation with any marker of sperm quality.

K. Tremellen and O. Tunc

Publisher: Blackwell Science Ltd
Contributor: Obstetrics and Gynaecology

Other identifier: International Journal of Andrology, 2010; 33:1-9; 0105-6263; 0020100555; 10.1111/j.1365-2605.2009.01037.x
Language: en
Rights: © 2010 The Authors. Journal compilation © 2010 European Academy of Andrology
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The presence of leucocytes within semen has the potential to impair sperm function. Neutrophils and macrophages make up 95% of seminal leucocytes, with both having the ability to damage sperm via the generation of reactive oxygen species, proteases and the ...
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Seminal Transforming Growth Factor B1 Stimulates Granulocyte-Macrophage Colony-Stimulating Factor Production and Inflammatory Cell Recruitment in the Murine Uterus

Author/Creator: Tremellen, K. P., Seamark, R. F., Robertson, Sarah A.
Resource type: journal article
Date: 1998, 2006
Subject: No Subjects
Record contributed by: The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/8047
http://link.library.adelaide.edu.au/?atitle=Seminal%20Transforming%20Growth%20Factor%20B1%20Stimulates%20Granulocyte-Macrophage%20Colony-Stimulating%20Factor%20Production%20and%20Inflammatory%20Cell%20Recruitment%20in%20the%20Murine%20Uterus&aulast=Tremellen&issn=0006-3363&title=Biology%20of%20Reproduction&volume=58&date=1998&pages=1217-1225&spage=1217&epage=1225
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http://hdl.handle.net/2440/8047
http://link.library.adelaide.edu.au/?atitle=Seminal%20Transforming%20Growth%20Factor%20B1%20Stimulates%20Granulocyte-Macrophage%20Colony-Stimulating%20Factor%20Production%20and%20Inflammatory%20Cell%20Recruitment%20in%20the%20Murine%20Uterus&aulast=Tremellen&issn=0006-3363&title=Biology%20of%20Reproduction&volume=58&date=1998&pages=1217-1225&spage=1217&epage=1225

Description
None Available


Other identifier: Biology of Reproduction. 58:1217-1225; 0006-3363; 0019980863
Language: en_US
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None Available
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Seminal 'priming' for protection from pre-eclampsia - a unifying hypothesis

Author/Creator: Robertson, Sarah A., Bromfield, J. J., Tremellen, K. P.
Resource type: journal article
Date: 2003, 2006
Subject: Semen; Seminal plasma; Leukocytes; Transforming growth factor-β; Pre-eclampsia
Record contributed by: The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/8336
http://link.library.adelaide.edu.au/?atitle=Seminal%20'priming'%20for%20protection%20from%20pre-eclampsia%20-%20a%20unifying%20hypothesis&aulast=Robertson&issn=0165-0378&title=Journal%20of%20Reproductive%20Immunology&volume=59&date=2003&pages=253-265&spage=253&epage=265
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http://hdl.handle.net/2440/8336
http://link.library.adelaide.edu.au/?atitle=Seminal%20'priming'%20for%20protection%20from%20pre-eclampsia%20-%20a%20unifying%20hypothesis&aulast=Robertson&issn=0165-0378&title=Journal%20of%20Reproductive%20Immunology&volume=59&date=2003&pages=253-265&spage=253&epage=265

Description
Copyright © 2003 Elsevier Science Ireland Ltd. All rights reserved.

Conventional belief holds that an immune response to ejaculate antigens should interfere with fertilisation and establishment of pregnancy. However, emerging evidence now supports the opposing view—that insemination acts to activate maternal immune mechanisms exerting a positive effect on reproductive events. In a response well documented in rodents, semen triggers an influx of antigen-presenting cells into the female reproductive tract which process and present paternal ejaculate antigens to elicit activation of lymphocytes in the adaptive immune compartment. Transforming growth factor beta (TGFβ), a cytokine present in abundance in seminal plasma, initiates this inflammatory response by stimulating the synthesis of pro-inflammatory cytokines and chemokines in uterine tissues. Lymphocyte activation is evident in lymph nodes draining the uterus and leads to hypo-responsiveness in T-cells reactive with paternal alloantigens. TGFβ has potent immune-deviating effects and is likely to be the key agent in skewing the immune response against a Type-1 bias. Prior exposure to semen in the context of TGFβ can be shown to be associated with enhanced fetal–placental development late in gestation. In this paper, we review the experimental basis for these claims and propose the hypothesis that, in women, the partner-specific protective effect of insemination in pre-eclampsia might be explained by induction of immunological hypo-responsiveness conferring tolerance to histocompatibility antigens present in the ejaculate and shared by the conceptus.

http://www.elsevier.com/wps/find/journaldescription.cws_home/506024/description#description

Publisher: Elsevier
Contributor: School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology

Other identifier: Journal of Reproductive Immunology, 2003; 59 (2):253-265; 0165-0378; 0020030460; 000184965800015
Language: en_US
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Conventional belief holds that an immune response to ejaculate antigens should interfere with fertilisation and establishment of pregnancy. However, emerging evidence now supports the opposing view—that insemination acts to activate maternal immune mechanisms ...
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Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue

Author/Creator: Jasper, Melinda Jane, Tremellen, Kelton P., Robertson, Sarah A.
Resource type: journal article
Date: 2006, 2007
Subject: cytokine; endometrium; Foxp; implantation failure; IVF; regulatory T cell (3)
Record contributed by: The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/23169
http://link.library.adelaide.edu.au/?atitle=Primary%20unexplained%20infertility%20is%20associated%20with%20reduced%20expression%20of%20the%20T-regulatory%20cell%20transcription%20factor%20Foxp3%20in%20endometrial%20tissue&issn=1360-9947&title=Molecular%20Human%20Reproduction&volume=12&issue=5&pages=301-308&spage=301&epage=308
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http://hdl.handle.net/2440/23169
http://link.library.adelaide.edu.au/?atitle=Primary%20unexplained%20infertility%20is%20associated%20with%20reduced%20expression%20of%20the%20T-regulatory%20cell%20transcription%20factor%20Foxp3%20in%20endometrial%20tissue&issn=1360-9947&title=Molecular%20Human%20Reproduction&volume=12&issue=5&pages=301-308&spage=301&epage=308

Description
Melinda J. Jasper, Kelton P. Tremellen, and Sarah A. Robertson

Publisher: Oxford University Press
Contributor: School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology

Other identifier: Molecular Human Reproduction, 2006; 12 (5):301-308; 1360-9947; 0020060688; 10.1093/molehr/gal032; 000237931200003
Language: en
Source: http://molehr.oxfordjournals.org/cgi/content/abstract/12/5/301
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Melinda J. Jasper, Kelton P. Tremellen, and Sarah A. Robertson
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The effect of intercourse on pregnancy rates during assisted human reproduction

Author/Creator: Tremellen, Kelton Paul, Norman, Robert J.
Resource type: letter or note
Date: 2001, 2007
Subject: No Subjects
Record contributed by: The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/32825
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.volume=16&rft.atitle=The%20effect%20of%20intercourse%20on%20pregnancy%20rates%20during%20assisted%20human%20reproduction&rft.aulast=Tremellen&rft.place=Great%20Clarendon%20St%20Oxford%20England%20OX2%206DP&rft.spage=2029&rft.issn=02681161&rft.jtitle=Human%20Reproduction&rft.issue=9&rft.epage=2030&rft.pub=Oxford%20Univ%20Press&rft.pages=2029-2030
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http://hdl.handle.net/2440/32825
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.volume=16&rft.atitle=The%20effect%20of%20intercourse%20on%20pregnancy%20rates%20during%20assisted%20human%20reproduction&rft.aulast=Tremellen&rft.place=Great%20Clarendon%20St%20Oxford%20England%20OX2%206DP&rft.spage=2029&rft.issn=02681161&rft.jtitle=Human%20Reproduction&rft.issue=9&rft.epage=2030&rft.pub=Oxford%20Univ%20Press&rft.pages=2029-2030

Description
Copyright © 2001 European Society of Human Reproduction and Embryology

Kelton Tremellen and Robert Norman

Publisher: Oxford University Press - European Society of Human Reproduction and Embryology
Contributor: School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology

Other identifier: Human Reproduction, 2001; 16 (9):2029-2030; 0268-1161; 0020012838; 10.1093/humrep/16.9.2029
Language: en
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Copyright © 2001 European Society of Human Reproduction and Embryology
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Management of fertility issues in cancer survivors

Author/Creator: Tremellen, Kelton Paul, Petrucco, Oswald Marino
Resource type: journal article
Date: 2003, 2010
Subject: No Subjects
Record contributed by: The University of Adelaide

Full Record and related resources:
http://hdl.handle.net/2440/56693
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.volume=32&rft.atitle=Management+of+fertility+issues+in+cancer+survivors+(ERA)&rft.aulast=Tremellen&rft.place=United+Kingdom&rft.spage=15&rft.issn=03008495&rft.jtitle=Australian+Family+Physician&rft.issue=1-2&rft.epage=18&rft.pub=Royal+Australian+College+of+General+Practitioners&rft.pages=15-18
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http://hdl.handle.net/2440/56693
http://link.library.adelaide.edu.au/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.volume=32&rft.atitle=Management+of+fertility+issues+in+cancer+survivors+(ERA)&rft.aulast=Tremellen&rft.place=United+Kingdom&rft.spage=15&rft.issn=03008495&rft.jtitle=Australian+Family+Physician&rft.issue=1-2&rft.epage=18&rft.pub=Royal+Australian+College+of+General+Practitioners&rft.pages=15-18

Description
BACKGROUND: With improved survival of cancer patients, the issue of fertility after treatment assumes greater importance. Consideration of fertility preserving measures before treatment needs to be considered. OBJECTIVE: To discuss an approach to management of fertlity issues in survivors of cancer. DISCUSSION Sensitive early counselling on fertility options is important to cancer survivors hoping to achieve a pregnancy. Assessment of fertility, the safety of a possible pregnancy and the impact of cancer treatments on future fertility treatments all need to be considered.

http://www.racgp.org.au/afp/200301/28943

Publisher: Royal Australian College of General Practitioners
Contributor: School of Paediatrics and Reproductive Health : Obstetrics and Gynaecology

Other identifier: Australian Family Physician, 2003; 32(1-2):15-18; 0300-8495; 0020095292
Language: en
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BACKGROUND: With improved survival of cancer patients, the issue of fertility after treatment assumes greater importance. Consideration of fertility preserving measures before treatment needs to be considered. OBJECTIVE: To discuss an approach to management ...
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